BREAST CANCER

A Personalized, Non-Invasive Treatment For Breast Cancer

Breast cancer treatment that revolves around you.

You have more options than ever for effectively treating breast cancer. But there is no one-size-fits-all treatment. You are unique. Your body, your lifestyle, your values and the specifics of your cancer all play a role in shaping your ideal treatment. The Radixact® System provides a personalized, precise and non-invasive option for treating your breast cancer, typically post lumpectomy or mastectomy. The system is the world’s only helical radiotherapy platform, delivering highly accurate radiation dose from 360 degrees around the patient.

A more precise option: Treat the cancer. Protect healthy tissue.

The Radixact System with the TomoTherapy® technology is designed to help improve clinical outcomes, while minimizing the risk of side effects, to protect your quality of life both during and after treatment. Two treatment delivery modes (TomoHelical and TomoDirect) offer unique advantages in the treatment of breast cancer, including the ability to deliver precise radiation dose to any tumor or tumor bed, during every treatment, while minimizing dose to nearby healthy organs and tissues. This is especially important for women diagnosed with cancer in the left breast, where the tumor may be close to critical organs such as the heart.

Key treatment facts about the Radixact System using TomoTherapy technology

  • Treats the full spectrum of breast cancer cases
  • Non-surgical and non-invasive
  • Reduces common side effects1
  • Treatments typically completed in daily sessions over several weeks

Ask a physician if Radixact treatment is right for you

You deserve the best possible treatment for your breast cancer. Find a physician in your area offering the Radixact System — and find out if Radixact treatment is right for you.

  • Clinically Proven Outcomes
  • A Non-Invasive Option
  • Enabling Re-Treatment
  • Radixact Vs. Traditional Treatments

An ideal solution for routine & complex breast cancers

The Radixact System with TomoTherapy technology is one of the most integrated, advanced systems for comprehensive cancer treatment available today and can be used to treat the full spectrum of breast cancers — from routine to complex tumors, those located in hard-to-reach areas and recurrent tumors. Several studies conducted using the TomoTherapy technology have shown good results.

  • The TomoDirect treatment method provided uniform delivery of radiation dose to the whole breast with minimal dose to nearby organs at risk. Patients experienced mild toxicity and no local recurrence at a mean follow-up of 12 months. Cosmesis – preservation of the normal appearance of the breast – was good/excellent in 91 percent of patients treated2
  • A prospective single-center study of 30 patients using TomoHelical for irradiation of Stage III breast cancer found that the treatments were very well tolerated with minimal acute or moderately late side effects. Cardiac and respiratory tests did not show evidence of significant treatment-related abnormalities. No local recurrence of the cancer had been recorded at the completion of the study3
  • A retrospective single-center study of 136 patients with invasive breast cancer found that hypofractionated radiotherapy delivered with helical TomoTherapy was very well tolerated with minimal acute and late toxicities. Additionally, this treatment modality provided excellent three-year loco-regional failure free survival, meaning there was no local or regional recurrence or tumor progression, or death due to breast cancer, three years after treatment4
  • A retrospective, single-center study evaluated the use of helical TomoTherapy to deliver radiation treatments post-surgery – either breast-conserving surgery (lumpectomy) or mastectomy – to 179 patients. The study showed that the TomoTherapy System optimized radiation delivery to the tumor site, while minimizing radiation delivery to nearby organs, including the lungs and heart. Treatment was well-tolerated and provided good local and distant disease control5

An ideal, non-invasive option

Radiation therapy may be used to treat breast cancer at almost every stage and can be used after surgery, chemotherapy and other medications. It is commonly used to help reduce risk of breast cancer recurrence and also can be used to provide relief from symptoms, such as pain, associated with advanced breast cancer.

The Radixact System provides the flexibility to adapt radiation therapy to any breast cancer patient’s anatomy, maximizing the radiation delivered to cancerous tissue while minimizing dose to the heart, lungs, other sensitive organs and surrounding healthy tissue.

Treatment with the system is a non-surgical, non-invasive, outpatient procedure that does not require incisions or general anesthesia. Most patients will not require hospitalization or a long recovery time.

Enabling re-treatment

Because the precise targeting of the Radixact System significantly reduces irradiation of surrounding healthy tissues, breast cancer patients treated with the Radixact System may sometimes be candidates for surgical interventions, in the event of recurrence. Under certain circumstances, patients may also undergo additional radiation treatments.

An effective, less disruptive treatment option

The Radixact System maximizes radiation delivered to the target — while helping to minimize dose to surrounding healthy tissues. The result is highly personalized treatment designed to significantly reduce the risk of the side effects that too often disrupt the lives of patients during and after treatment. Studies support the use of the TomoTherapy System for the treatment of breast cancer and show evidence of very good tumor control2, 6, 7, 8 with minimal radiation delivered to surrounding organs at risk (heart, lungs, etc.) and healthy tissues, and low toxicity3,4. The treatment regimens described in the studies reinforce the benefits of the unique capabilities of the TomoTherapy platform and what clinicians and their patients could expect to see with the Radixact System.

RADIXACT AFTER SURGERY

Radixact treatment is an outpatient procedure that does not require incisions or general anesthesia. Most patients will not require hospitalization or a long recovery period.

RADIXACT VS. BRACHYTHERAPY

Radixact treatment eliminates the inconvenience and risk associated with radioactive seed or catheter implants.

Find a Radixact Treatment Center

Learn More About Radixact Treatment

References:

1 Buwenge M, Cammelli S, Ammendolia I, et al. “Intensity modulated radiation therapy for breast cancer: current perspectives.” Breast Cancer Targets Ther. 2017;9:121–126.

2 Franco et al. “Intensity-modulated and hypofractionated simultaneous integrated boost adjuvant breast radiation employing statics ports of TomoTherapy (TomoDirect): a prospective phase II trial.” J Cancer Res Clin Oncol. 2014 Jan;140(1):167-77. doi: 10.1007/s00432-013-1560-8.

3 Caudrelier et al. “IMRT sparing of normal tissues in locoregional treatment of breast cancer.” Radiat Oncol. 2014 Jul 22;9:161. doi: 10.1186/1748-717X-9-161.

4 Chitapanarux I, Nobnop W, Tippanya D et al. “Clinical outcomes and dosimetric study of hypofractionated Helical tomotherapy in breast cancer patients.” PLoS One. 2019 Jan 31;14(1):e0211578.

5 Arsene-Henry A, Foy JP, Robilliard M et al. “The use of helical tomotherapy in the treatment of early stage breast cancer: indications, tolerance, efficacy-a single center experience.” Oncotarget. 2018 May 4;9(34):23608-23619.

6 O’Donnell et al. “Early Experience of TomoTherapy-based Intensity-modulated Radiotherapy for Breast Cancer Treatment.” Clinical Oncology 2009 21: 294-301.

7 Van Prijs et al. “Short course radiotherapy with simultaneous integrated boost for stage I-II breast cancer, early toxicities of a randomized clinical trial.” Radiation Oncology 2012, 7:80.

8 Michalski et al. “A dosimetric comparison of 3D-CRT, IMRT and static tomotherapy with an SIB for large and small breast volumes.” Medical Dosimetry. 2014 Summer;39(2):163-8. doi: 10.1016/j.meddos.2013.12.003.

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