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Non-Invasive Cervical Cancer Treatment – Tailored to You

A treatment for cervical cancer that revolves around you.

Advances in care mean there are effective treatments for people diagnosed with cervical cancer that can be adapted for their particular medical condition. Radiation therapy is one of the key treatment options. The TomoTherapy® platform, including the next-generation Radixact® System, is the first in the world that is capable of helical radiation delivery – continuously delivering high-quality helical fan-beam imaging for accurate image-guided, intensity-modulated radiation therapy (IG-IMRT) from multiple 360 degree rotations around your body – providing a highly precise, personalized and non-invasive option for treating various stages of cervical cancer.

A more precise option: Treat the cancer. Minimize damage to healthy tissue.

Radiation therapy is a proven treatment for cervical cancer, and is typically used in combination with chemotherapy with the ultimate goal of curing the disease. Radiation therapy can also be used to treat cancer that has spread or has come back after treatment. However, radiation delivered to surrounding organs, such as the bladder, rectum or bowel, may lead to life-changing side effects, making it critically important for the radiation to be delivered with extreme accuracy and precision. The Radixact System, featuring TomoTherapy technology, combines unique 360 degree treatment delivery from multiple rotations around the patient’s body with powerful dose-sculpting capabilities, providing greater control of the radiation dose so it conforms precisely to the tumor and helps minimize dose to healthy tissue. The result is a radiation therapy treatment that maximizes effectiveness while helping to preserve genitourinary and gastrointestinal function, which may lead to better quality of life for patients both during and after treatment.

Key treatment benefits of the Radixact System using TomoTherapy technology

  • Non-surgical and non-invasive
  • Good cancer control
  • Significantly reduces common side effects 1,2 3,4
  • Most patients can continue normal activity throughout treatment
  • Can be used in combination with chemotherapy and before brachytherapy

Ask a physician if Radixact treatment is right for you

You deserve the best possible treatment for your cervical cancer. Find a physician in your area offering the Radixact System — and find out if Radixact treatment is right for you.

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A clinically proven treatment for cervical cancer

The Radixact System with TomoTherapy technology is one of the most integrated, advanced systems for comprehensive cancer treatment available today. The Radixact System enables precise delivery of IG-IMRT, an advanced type of IMRT, for the treatment of cervical cancer. The use of the TomoTherapy technology, as well as IMRT, are supported by published clinical studies.

  • An analysis of multiple, independent studies (meta-analysis) found that cervical cancer patients treated with intensity-modulated radiation therapy (IMRT) experienced significantly reduced acute gastrointestinal (GI) and genitourinary (GU) toxicities, and chronic GU toxicity, than patients in the control group treated with three-dimensional conformal radiation therapy (3DCRT) or 2DCRT 1.
  • A study evaluated the use of helical TomoTherapy to deliver whole pelvic IMRT in patients with locally advanced cervical cancer. Helical TomoTherapy treatment plans were compared to those created for conventional whole pelvic radiation therapy (WPRT). The study found treatment with TomoTherapy is a viable option. Additionally, the helical TomoTherapy treatment plans successfully reduced the radiation dose to be delivered to the rectum, bladder and intestines, compared to the conventional WPRT plans 2.
  • A randomized, controlled study evaluating patients with locally advanced cervical cancer treated with whole pelvic conventional radiation therapy or IMRT found that IMRT was associated with significantly less acute GI toxicities and chronic GU toxicity compared with CRT, with comparable effectiveness outcomes 3.
  • Patients with cervical cancer were treated with IMRT or 3DCRT as part of a multi-treatment regimen. The study found that IMRT provides a good treatment option with reduced acute GI and GU toxicities compared to 3DCRT 4.
  • A treatment planning comparison study showed that, for cervical cancer patients who were treated with post-operative external beam radiation therapy, IMRT achieved better sparing of organs at risk, including the bladder, rectum and bowel, than 3DCRT 5.
  • Results of a randomized study designed to compare cervical and endometrial cancer patients’ perspective of acute toxicity and quality of life during treatment with standard pelvic radiation or IMRT found that IMRT resulted in less impact on bowel and urinary function during treatment. Patients treated with IMRT also reported a smaller decline in physical function and other treatment-related concerns over the course of their treatment 6.

IG-IMRT: A more precise option for cervical cancer treatment

Radiation therapy can provide a non-surgical, non-invasive treatment option for many cervical cancer patients. An extremely precise type of radiation therapy, called image-guided, intensity-modulated radiotherapy (IG-IMRT), may offer superior dose-delivery to enhance treatment efficacy while helping to reduce the risk of effects.

The TomoTherapy platform, including the next-generation Radixact System, is the only system designed from the ground up to deliver IG-IMRT and was the first to feature helical radiation delivery and integrated CT imaging – providing greater control of the radiation dose so it conforms precisely to the tumor and helps minimize dose to healthy tissue.

Instead of a single beam of radiation, the TomoTherapy platform divides each beam into many smaller, narrow “beamlets.” Every beamlet is individually optimized to a specific intensity of radiation that is targeted at the tumor, enabling customized and precise treatment delivery. Thousands of these beamlets combine in the tumor to contribute to the total radiation dose each patient has been uniquely prescribed. This is called intensity-modulated radiation therapy (IMRT). An enhanced form of IMRT – image-guided intensity-modulated radiation therapy
(IG-IMRT) – uses images acquired before each treatment to help ensure accurate patient and tumor positioning.

A non-invasive option

As with other cancers, the treatment selected for cervical cancer depends in part on its stage. For early stages, your doctor may recommend radiation (brachytherapy) alone followed by surgery.

For all other stages, radiation and chemotherapy may be given at the same time (referred to as concurrent chemoradiation) and may be the preferred treatment. External beam radiation therapy (EBRT), delivered with machines like the Radixact System, may be used as the main treatment of cervical cancer, usually combined with chemotherapy and followed by brachytherapy. Your doctor may also use EBRT to treat cervical cancers that have spread to other organs and tissues, or cancer that has come back after initial treatment.

The Radixact System provides the flexibility to adapt radiation therapy to any cervical cancer patient’s anatomy, helping to enable the delivery of extremely precise and accurate radiation doses to improve treatment outcomes and help reduce the risk of side effects that may impact patients’ quality of life.

Treatment with the Radixact System is a non-surgical, non-invasive, outpatient procedure that does not require incisions or general anesthesia. Most patients will not require hospitalization or a long recovery time.

Enabling re-treatment

Because the precise targeting of the Radixact System significantly reduces irradiation of surrounding healthy tissues, the Radixact System could be a powerful treatment option for patients who have previously undergone radiation or surgical procedures, and experience a recurrence.

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References:

1 Lin Y., Chen K., Lu Z. et al. Intensity-modulated radiation therapy for definitive treatment of cervical cancer: a meta-analysis. Radiat Oncol. 2018 Sep 14;13(1):177.

2 Hsieh C.H., Wei M.C., Lee H.Y. et al. Whole pelvic helical tomotherapy for locally advanced cervical cancer: technical implementation of IMRT with helical tomotherapy. Radiat Oncol. 2009 Dec 10;4:62.

3 Gandhi A.K., Sharma D.N., Rath G.K. et al. Early clinical outcomes and toxicity of intensity modulated versus conventional pelvic radiation therapy for locally advanced cervix carcinoma: a prospective randomized study. Int J Radiat Oncol Biol Phys. 2013 Nov 1;87(3):542-8.

4 Naik A, Gurjar OP, Gupta KL, Singh K, Nag P, Bhandari V. Comparison of dosimetric parameters and acute toxicity of intensity-modulated and three-dimensional radiotherapy in patients with cervix carcinoma: A randomized prospective study. Cancer Radiother. 2016 Jul;20(5):370-6.

5 Marjanovic D., Plesinac Karapandzic V., Stojanovic Rundic S. et al. Implementation of intensity-modulated radiotherapy and comparison with three-dimensional conformal radiotherapy in the postoperative treatment of cervical cancer. J BUON. 2019 Sep-Oct;24(5):2028-2034.

6 Klopp A.H., Yeung A.R., Deshmukh S. et al. Patient-Reported Toxicity During Pelvic Intensity-Modulated Radiation Therapy: NRG Oncology-RTOG 1203. J Clin Oncol. 2018 Aug 20;36(24):2538-2544.

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Important Safety Statement: Most side effects of radiotherapy, including radiotherapy delivered with Accuray systems, are mild and temporary, often involving fatigue, nausea, and skin irritation. Side effects can be severe, however, leading to pain, alterations in normal body functions (for example, urinary or salivary function), deterioration of quality of life, permanent injury and even death. Side effects can occur during or shortly after radiation treatment or in the months and years following radiation. The nature and severity of side effects depend on many factors, including the size and location of the treated tumor, the treatment technique (for example, the radiation dose), the patient’s general medical condition, to name a few. For more details about the side effects of your radiation therapy, and if treatment with an Accuray product is right for you, ask your doctor.